Provided that your Vampire the Masquerade setting has nothing in common with the stock setting (e.g., no location names or NPCs in common), we are fine with it using the general world rules of VtM as a basis for an original character. For a brief idea of what this extends to, consider: no Camarilla, no Masquerade, no Kindred, no Cainite Heresy, no Tremeres. In short, no World of Darkness. This would be a world that merely uses the VtM play system to tell its own story in its own setting. We hope this clarifies.
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Provided that your Vampire the Masquerade setting has nothing in common with the stock setting (e.g., no location names or NPCs in common), we are fine with it using the general world rules of VtM as a basis for an original character. For a brief idea of what this extends to, consider: no Camarilla, no Masquerade, no Kindred, no Cainite Heresy, no Tremeres. In short, no World of Darkness. This would be a world that merely uses the VtM play system to tell its own story in its own setting. We hope this clarifies.